Journal
CANCER LETTERS
Volume 319, Issue 2, Pages 136-143Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2011.12.042
Keywords
Elastin-like polypeptide; c-Myc; Thermal targeting; Therapeutic peptide; Breast cancer
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Funding
- NIH from the MFGN INBRE of the National Center for Research Resources [RR016476]
- Department of Defense [W81XWH-08-1-0647]
- NSF [CBET-0931041]
- National Cancer Institute [R21 CA113813-01A2]
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Although surgical resection with adjuvant chemotherapy and/or radiotherapy are used to treat breast tumors, normal tissue tolerance, development of metastases, and inherent tumor resistance to radiation or chemotherapy can hinder a successful outcome. We have developed a thermally responsive polypeptide, based on the sequence of Elastin-like polypeptide (ELP), that inhibits breast cancer cell proliferation by blocking the activity of the oncogenic protein c-Myc. Following systemic administration, the ELP - delivered c-Myc inhibitory peptide was targeted to tumors using focused hyperthermia, and significantly reduced tumor growth in an orthotopic mouse model of breast cancer. This work provides a new modality for targeted delivery of a specific oncogene inhibitory peptide, and this strategy may be expanded for delivery of other therapeutic peptides or small molecule drugs. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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