Journal
MINI-REVIEWS IN MEDICINAL CHEMISTRY
Volume 7, Issue 1, Pages 79-86Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138955707779317885
Keywords
nuclear hormone receptors; thyroid hormones receptors; thyroid hormones agonists; X-ray; metabolic rate; cholesterol; heart rate; structure-activity-relationship (SAR); beta-selective
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This mini-review will provide an overview on the recent design principles and structure-activity-relationship of beta-selective thyroid hormone receptor (TR) agonists. The prospects for the treatment of metabolic diseases as dyslipidemia with TR beta-selective ligands are considerable enough so as to avoid cardiovascular acceleration mediated through TR alpha.
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