Journal
CANCER LETTERS
Volume 302, Issue 2, Pages 136-143Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2011.01.009
Keywords
Malignant pleural mesothelioma; Epithelial-to-mesenchymal transition; Cell polarity; Stemness features
Categories
Ask authors/readers for more resources
Epithelial-to-mesenchymal transition (EMT) is the fundamental process by which an epithelial cell loses its epithelial characteristics including cell polarity and acquires mesenchymal and sternness-related features. Therefore, we investigated whether malignant pleural mesothelioma (MPMs) histologies were associated with specific patterns of expression of a selected set of genes related to EMT, cell polarity and sternness features. The association between MPM histologies and genes expression were explored using active and passive Principal Components Analysis-based biplots and PAM analysis that provided evidence that with respect to normal tissues. MPMs histologies were better characterized by specific patterns of expression of genes involved in EMT activation, cell polarity and sternness. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available