Journal
GENE EXPRESSION PATTERNS
Volume 7, Issue 3, Pages 306-312Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.modgep.2006.08.006
Keywords
R-spondin; Wnt; frizzled; LRP5/6; beta-catenin; mouse embryogenesis; gene expression
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Funding
- NCRR NIH HHS [P20 RR018789] Funding Source: Medline
- NATIONAL CENTER FOR RESEARCH RESOURCES [P20RR018789] Funding Source: NIH RePORTER
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R-spondins (Rspo) are a recently discovered secretory protein family with four members in human and mouse. We and others demonstrated that R-spondins can activate canonical Writ signaling and beta-catenin-dependent gene expression. Our study further demonstrated that R-spondins are novel ligands for the Frizzled8 and LRP6 (LDL-receptor-related protein 6) receptors. To gain insight into their biological functions, the RNA expression pattern of the mouse R-spondin family genes was analyzed during mouse development. Our study shows that R-spondin gene transcripts are widely expressed with distinct patterns in mouse at different developmental stages. (c) 2006 Elsevier B.V. All rights reserved.
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