Journal
CANCER LETTERS
Volume 300, Issue 2, Pages 180-188Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2010.10.004
Keywords
Chemokine; Angiogenesis; Metastasis; Colon cancer
Categories
Funding
- National Cancer Institute National Institutes of Health [CA72781, P30CA036727]
- Nebraska Research Initiative Cancer Glycomics Program
- Schering-Plough Research Institute
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CXCR1 and CXCR2 are G-protein coupled receptors that have been shown to play important role in tumor growth and metastasis and are prime targets for the development of novel therapeutics Here we report that targeting CXCR2 and CXCR1 activity using orally active small molecule antagonist (SCH-527123 SCH-479833) inhibits human colon cancer liver metastasis mediated by decreased neovascularization and enhanced malignant cell apoptosis There were no differences in primary tumor growth These studies demonstrate the important role of CXCR2/1 in colon cancer metastasis and that inhibition of CXCR2 and CXCR1 small molecule antagonists provides a novel therapeutic strategy (C) 2010 Elsevier Ireland Ltd All rights reserved
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