Journal
CANCER LETTERS
Volume 309, Issue 2, Pages 209-219Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2011.06.009
Keywords
Colorectal cancer; Fibroblast growth factor receptor 2; The invasive front; Growth
Categories
Funding
- [22591531]
- [22689038]
- [22791552]
- [22790675]
- Grants-in-Aid for Scientific Research [22791552, 23590477] Funding Source: KAKEN
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Fibroblast growth factor receptor 2 (FGFR2) is considered a novel therapeutic target for various cancer. We used a silencing strategy to clarify the effect of reduced FGFR2 expression in human colorectal cancer (CRC) cells. The invasive front of cancer cells exhibited stronger FGFR2 expression than the surface area of the cancers. FGFR2 shRNA-transfected LoVo cells inhibited cell migration, invasion and tumor growth in vitro and in vivo. Thus, FGFR2 plays important roles in CRC progression in association with tumor cell migration, invasion and growth, and FGFR2 might be a novel therapeutic target for CRC. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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