Journal
PHARMACEUTICAL BIOLOGY
Volume 45, Issue 5, Pages 376-380Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/13880200701214821
Keywords
Clidemia sericea; flavonoid glycosides; ICBG; leishmania; malaria; Mosquitoxylum jamaicense; tropical diseases; Trypanosoma cruzi
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A new O-galloyl-C-glycosylflavone, 2 '',6 ''-O-digalloylvitexin (1), along with four known glycosylflavones (2 -5) have been isolated from Clidemia sericea D. Don (Melastomataceae), and four other known glycosylflavones (6 -9) have been isolated from Mosquitoxylon jamaicense Krug & Urb. (Anacardiaceae). Compound 1, 3, and 6 showed mild antimalarial activity (24 +/- 1, 38 +/- 2, and 44 +/- 1 mu M, respectively) against a chloroquine-resistant P. falciparum strain. Additionally, tests against leishmaniasis and Trypanosoma cruzi were made. These compounds were identified by MS, UV, IR, and 1D and 2D NMR data and by comparison with the literature data.
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