Journal
CANCER LETTERS
Volume 308, Issue 1, Pages 23-32Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2011.04.010
Keywords
TGFBI; Metastasis; Extracellular matrix; Adhesion-mediated signaling; Mouse model
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Funding
- National Institutes of Health [ES05786, CA49062, ES09089]
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Controversy has arisen as to the role of transforming growth factor-beta-induced protein (TGFBI) in the regulation of tumor metastasis. Using lung and breast cancer cell lines (H522 and MCF-7, respectively), we established that TGFBI induced cell adhesion to extracellular matrix proteins by activating adhesion-associated signaling and subsequent structure reformation, ultimately leading to cells less motile; whereas TGFBI reduced abilities of colony formation in soft agar, penetration through matrix gel, and activation of matrix metalloproteinases 2 and 9. Furthermore, injection of TGFBI-expressing cells into immuno-deficient mice resulted in a significant reduction in tumor metastasis in vivo. Taken together, these data suggest that TGFBI moderates the metastatic potential of cancer cells. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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