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Hypoxia-inducible factors in OSCC

Journal

CANCER LETTERS
Volume 313, Issue 1, Pages 1-8

Publisher

ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2011.08.017

Keywords

Oral squamous cell carcinoma; Hypoxia-inducible factors; HIF-1 alpha; HIF-2 alpha; Hypoxia

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Oral squamous cell carcinoma (OSCC) is a characteristic locally aggressive tumor in which hypoxia levels are very high, causing a low response to chemotherapy and providing basic resistance to anticancer drugs. Tumoral hypoxia directly depends on hypoxia-inducible factors (HIF). The goal of this paper is to describe HIF basic biology and tumor cells (HIF-1 alpha, mainly), analyzing the effects of its expression in OSCC, study its relation with other molecules such as nitric oxide (NO), carbonic anhydrase (CA) or VEGF and assess the possibility of its manipulation as a therapeutic target. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

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