Journal
CANCER LETTERS
Volume 312, Issue 2, Pages 150-157Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2011.07.028
Keywords
Hepatocellular carcinoma; Bleomycin hydrolase; Tumor suppressor gene; Expression array; Single nucleotide polymorphism array; Methylation array
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Funding
- Grants-in-Aid for Scientific Research [22591427] Funding Source: KAKEN
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In the present study, we sought to identify novel suppressor genes of hepatocellular carcinoma (HCC) using our newly designed triple-combination array. Using this method, the bleomycin hydrolase gene (BLMH) was detected as a candidate suppressor gene. We found that 28 of 48 (58.3%) tumor tissues showed BLMH promoter hypermethylation, and its expression level was significantly reduced in tumor tissues (P = 0.001). The present study suggests that our new method can detect novel genes of interest and that BLMH is a suppressor gene in HCC. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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