Journal
CANCER LETTERS
Volume 307, Issue 2, Pages 158-164Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2011.03.028
Keywords
Silybin; Nanosuspension; Antitumor; Cytotoxicity
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Funding
- National Basic Research Program of China (973Program) [2009CB 930300]
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The present study aims to evaluate the antitumor activity of silybin nanosuspension on human prostatic carcinoma PC-3 cell line in vitro. Silybin nanosuspension was prepared by the high pressure homogenization (HPH) method. MTT assay, observation of morphological changes and apoptotic body showed that silybin nanosuspension could significantly enhance the in vitro cytotoxicity against PC-3 cells compared to the silybin solution. Flow cytometric (FCM) analysis demonstrated that silybin nanosuspension induced G1 cycle arrest and apoptosis in PC-3 cells. Thereby, the overall results suggest that the silybin nanosuspension represents a potential source of medicine for the treatment of human prostate cancer. Crown Copyright (C) 2011 Published by Elsevier Ireland Ltd. All rights reserved.
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