Journal
MOLECULAR BIOTECHNOLOGY
Volume 35, Issue 1, Pages 65-97Publisher
HUMANA PRESS INC
DOI: 10.1385/MB:35:1:65
Keywords
single nucleotide polymorphism, SNP; genotyping; variation; polymorphism; online data-bases; linkage disequilibrium; haplotype; haplotype block; genome; HapMap; clinical genetics; population genetics
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The major online single nucleotide polymorphism (SNP) databases freely available as research tools for genetic analysis are explained, reviewed, and compared. An outline is given of the search strategies than can be used with the most extensive current SNP databases: National Centre for Biotechnology Information (NCBI) dbSNP and HapMap to help the user secure the most appropriate data for the research needs of clinical genetics and population genetics research. A range of online tools that can be useful in designing SNP genotyping assays are also detailed.
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