Journal
REPRODUCTIVE TOXICOLOGY
Volume 23, Issue 1, Pages 113-118Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.reprotox.2006.08.005
Keywords
organophosphorous; pyrethroid; insecticides; pesticides; reproduction; male; semen quality; hormones; chinese; pesticide mixtures
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Funding
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [P01ES006198, P30ES000002, R01ES008337, R01ES011682, K01ES010959] Funding Source: NIH RePORTER
- NIEHS NIH HHS [K01 ES10959, P01 ES06198, ES-00002, 1R01 ES11682, 1R01 ES08337] Funding Source: Medline
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Background: There is growing concern that poisoning and other adverse health effects are increasing because organophosphorous (OP) insecticides are now being used in combination with pyrethroid (PYR) insecticides to enhance the toxic effects of PYR insecticides on target insects, especially those that have developed PYR resistance. Objectives: We conducted a pilot biomonitoring study to determine whether men in our reproductive cohort study were being exposed to pesticides environmentally by virtue of frequenting an agricultural setting. Methods: We screened 18 randomly selected urine samples collected from male participants of reproductive age for 24 parent compounds and metabolites of pesticides and examined the results in relation to sperm concentration. Results: Results showed high prevalence of exposure to OP and PYR pesticides and our preliminary analyses provided some suggestion that the higher exposure group had lower sperm concentration. Conclusions: The potential of OP/PYR mixtures to have enhanced human toxicity needs more research attention. (c) 2006 Elsevier Inc. All rights reserved.
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