Journal
CANCER LETTERS
Volume 287, Issue 1, Pages 1-12Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2009.05.013
Keywords
Plant lectin; Cancer; Apoptosis; Autophagy; Drug
Categories
Funding
- National Natural Science Foundation of China [30270331, 30670469]
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Plant lectins, carbohydrate-binding proteins distributed widely in a variety of plant species, have drawn a rising attention for cancer biologists due to their remarkable anti-tumour properties. In this review, we present a brief outline of the up-to-date advances of plant lectins in elucidating their complex anti-cancer mechanisms implicated in apoptosis and autophagy. In addition, we further discuss the pre-clinical and clinical studies of plant lectins for their potential therapeutic applications. In conclusion, these inspiring findings would open a new perspective for plant lectins as potential antineoplastic drugs from bench to clinic. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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