Journal
CANCER LETTERS
Volume 291, Issue 1, Pages 99-107Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2009.10.005
Keywords
Choriocarcinoma; Gestation; MicroRNA; Mole; Placenta
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Funding
- Chang Gung Memorial Hospital [CMRPG360952, CMRPG360912]
- Taiwan National Science Council [NSC97-2314-B-182A-023-MY2, NSC96-2314-B-182A-124]
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We compared microRNA profiles between choriocarcinoma and non-cancerous trophoblasts, and revealed that miR-199b was underexpressed in choriocarcinoma. By computational prediction and microarray studies, SET (protein phosphatase 2A inhibitor) was shown to be one of the target genes regulated by miR-199b. Ectopic expression of miR-199b inhibited endogenous SET protein levels and the activity of the luciferase reporter containing the 3'-UTR of SET. Further comparisons of formalin-fixed paraffin-embedded human choriocarcinoma, mole, and non-cancer trophoblast tissues confirmed the initial findings of low miR-199b expression and SET upregulation in choriocarcinomas, suggesting that microRNA-dysregulated SET protein may account for the rapid growth seen with choriocarcinomas. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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