Journal
CANCER LETTERS
Volume 295, Issue 1, Pages 92-99Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2010.02.017
Keywords
p38 MAPK; NF-kappa B; Naphthoquinone; Hepatocellular carcinoma (HCC)
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Funding
- National Science Council, ROC [KMU-EM-98-6-2, KMU-EM-98-1-3, NSC 98-2314-B-037-035]
- National Sun Yat-Sen University-Kaohsiung Medical University Joint Research Center
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Naphtho[1,2-b] furan-4,5-dione (NFD) was investigated for its anti-proliferation effect on human hepatocellular carcinoma (HCC), Hep3B, HepG(2), and Huh-7 cells. The effect of NFD on inhibiting proliferation and apoptosis was correlated with up-regulation of proapoptotic protein and down-regulation of pro-survival proteins. Remarkably, we found that NFD inhibited the nuclear translocation of NF-kappa B, likely accounting for the down-regulation of pro-survival Bcl-2 family. Furthermore, suppression of p38 MAPK activity by a specific inhibitor significantly rescued the cell proliferation inhibited by NFD. These findings suggest that signaling imbalance between p38 MAPK and NF-kappa B by NFD results in the proliferative inhibition and apoptosis of HCC tumor cells. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
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