Journal
CANCER LETTERS
Volume 293, Issue 1, Pages 117-123Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2010.01.003
Keywords
Circulating tumor cells; Metastatic colorectal cancer; EpCAM; Progression-free survival
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Funding
- Austrian Research Promotion Agency (FFG)
- Janssen-Cilag Pharma, Austria
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Comprehensive in vitro and in vivo studies comparing EpCAM-based methods with other cytometric CTC enrichment technologies in metastatic colorectal cancer (mCRC) patients are lacking. We compare four manual cytometric methods to detect CTCs in vitro and in mCRC patients. The EpCAM-based technology, MACS HEA MicroBeads (R), showed a significant better tumor cell recovery rate compared to other cytometric methods (p-value <0.0001). CTCs of 38 mCRC patients were enriched with MACS HEA MicroBeads (R). Progression-free survival did significantly differ between mCRC patients without detectable and with >= 1 CTCs (p = 0.007). CTC enrichment with EpCAM coupled antibodies is superior to other cytometric methods and is a feasible method for CTC detection in mCRC patients. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
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