Journal
CANCER LETTERS
Volume 287, Issue 2, Pages 187-195Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2009.06.009
Keywords
Colon cancer; Tetrandrine; Apoptosis; Mitogen-activated protein kinase
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Funding
- Far Eastern Memorial Hospital, Taipei, Taiwan, ROC [FEMH 93-C-038, FEMH 94-C-019]
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Tetrandrine, a bisbenzylisoquinoline alkaloid, exerts antitumor effects against some cancers. We explored tetrandrine's effects on colon cancer with cultured mouse CT-26 cells and with subcutaneous tumors. Tetrandrine induced apoptosis in concentration- and time-dependent manner. Tetrandrine increased expression of ERK 1/2 and p38 MAPK; inhibition of p38 MAPK reduced tetrandrine-induced apoptosis; inhibition of ERK1/2 did not. Tetrandrine had significant effects on tumors including slower growth and longer animal survival time and higher survival rate. Higher dose and earlier treatment were more effective than lower dose and delayed treatment. TUNEL staining showed prominent tetrandrine-induced apoptosis of tumors. These data suggest that tetrandrine induced significant apoptosis of cultured and subcutaneous CT-26 cells. Tetrandrine-induced apoptosis might be at least partially related to activation of the p38 MAPK signaling pathway. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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