Journal
CANCER LETTERS
Volume 290, Issue 2, Pages 248-254Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2009.09.015
Keywords
Apoptosis; Esophageal squamous cell carcinoma (ESCC); mTOR; Rapamycin; Signaling pathway
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Funding
- 211 Project of the 10th Five-Year Plan (Education Ministry of China)
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Accumulating evidences have demonstrated that mTOR pathway has a central role not only in cell growth but also in invasion and metastasis of cancers. Here we reported that rapamycin or cisplatin alone inhibited significantly the tumor growth and their combination had the strongest anticancer effect on transplantable tumor growth of human ESCC cell line EC9706 in nude mice. Furthermore, western blots, RT-PCR and TUNEL assay revealed that rapamycin specifically blocked mTOR pathway and induced apoptosis of ESCC cells in vivo. These findings indicate a rationale for using mTOR inhibitors as a mechanism-based therapeutic approach to patients with ESCC. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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