Journal
CANCER LETTERS
Volume 299, Issue 1, Pages 11-21Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2010.07.019
Keywords
VIP; RWPE-1 cells; EMT; Tumorigenesis; Prostate cancer
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Funding
- Ministerio de Ciencia e Innovacion [SAF2007-63794]
- Comunidad Autonoma de Madrid/Universidad de Alcala [CCG06-UAH/SAL-0407]
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The carcinogenic potential of vasoactive intestinal peptide (VIP) was analyzed in non-tumor human prostate epithelial cells (RWPE-1) and in vivo xenografts VIP induced morphological changes and a migratory phenotype consistent with stimulation of expression/activity of metalloproteinases MMP-2 and MMP 9 decreased E cadherin-mediated cell-cell adhesion and increased cell motility VIP increased cyclin D1 expression and cell proliferation that was blocked after VPAC(1)-receptor siRNA transfection Similar effects were seen in RWPE-1 tumors developed by subcutaneous injection of VIP-treated cells in athymic nude mice VIP acts as a cytokine in RWPE 1 cell transformation conceivably through epithelial-mesenchymal transition (EMT) reinforcing VIP role in prostate tumorigenesis (C) 2010 Elsevier Ireland Ltd All rights reserved
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