Journal
TRENDS IN GENETICS
Volume 23, Issue 1, Pages 5-7Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tig.2006.10.002
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Two recent publications illuminate the evolution of alternative splicing, showing that a SR (serine-arginine-rich) protein that regulates alternative splicing in multicellular organisms is also found in a unicellular organism without alternative splicing, in which it cain assist in the splicing of weak introns. Moreover, insertion of SR proteins into an organism lacking such proteins can restore the splicing of weak introns. These results imply that SR proteins had already facilitated the splicing of weak introns before the evolution of alternative splicing.
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