Journal
CANCER LETTERS
Volume 288, Issue 1, Pages 1-9Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2009.05.020
Keywords
Side population; Cancer stem cells; Chemotherapy; Interferon
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Funding
- Associazione Italiana per la Ricerca Sul Cancro (AIRC)
- Fondazione Italiana per la Ricerca sul Cancro (FIRC)
- Ministry of University and Research
- Ministry of Health, Oncology Program
- Banca Popolare di Verona
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New studies indicate that the side population (SP) and cancer stem cells (CSC) drive and maintain many types of human malignancies. SP and CSC appear to be highly resistant to chemo- and radio-therapy and this knowledge is now reshaping our therapeutic approach to cancer. Several studies have pioneered the possibility of specifically targeting CSC and SP cells by exploiting pathways involved in drug resistance. or forcing these cells to proliferate and differentiate thus converting them into a target of conventional therapies. Moreover, certain cytokines - such as IFN-alpha - appear to modulate SP and stem cell functions, and this associates with remarkable therapeutic activity in animal models. These recent findings underscore the need of a more comprehensive view of the interactions between cytokines and key regulatory pathways in SP and CSC. (C) 2009 Published by Elsevier Ireland Ltd.
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