Journal
CANCER LETTERS
Volume 292, Issue 1, Pages 91-97Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2009.11.011
Keywords
Immunopathology; Nanoparticle conjugate; Surface enhanced Raman scattering; Chronic lymphocytic leukemia; Leukemia
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Funding
- Canadian Institute of Health Research
- Natural Sciences and Engineering Research Council of Canada
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Selective targeting and detection of a hematologic malignancy, chronic lymphocytic leukemia, using surface enhanced Raman scattering (SERS) gold nanoparticles is reported. The functional nanoparticles were composed of a gold core onto which an optical reporter dye was adsorbed, protected from aggregation by grafted polyethyleneglycol, and targeted to CD19 antigen by antibodies. The signals were detected by dark-field microscopy and Raman spectrometry. The observation that the Raman signals are not disrupted by several traditional pathology stains indicates advantages over fluorescence methods. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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