Journal
CANCER LETTERS
Volume 296, Issue 1, Pages 88-95Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2010.03.020
Keywords
Epidermal growth factor; Epithelial-mesenchymal transition; Esophageal squamous cell carcinoma; Metastasis
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Deciphering the molecular basis of esophageal cancer metastasis requires adequate experimental models. Epithelial-mesenchymal transition (EMT) is the hallmark of tumor metastasis. As a promoter of the malignant progression of esophageal cancer, epidermal growth factor (EGF) has been shown to induce EMT in several cell lines. In this study we examined the effects of EGF on esophageal carcinoma EC109 cells. We found that EGF at high concentration induced the cells to undergo morphological change, exhibit higher invasive and metastatic potential, as well as change in the expression of lineage markers. This EMT model might facilitate mechanistic studies of esophageal cancer metastasis. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
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