Journal
CANCER LETTERS
Volume 295, Issue 2, Pages 242-251Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2010.03.007
Keywords
MMP-9; Breast cancer cell line MCF-7; MDR1 phenotype; Cell migration; Tubular network; Signalling pathways
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Matrix metalloproteinase-9 (MMP-9) strongly influences tumor development and metastasis. Using resistant (rMCF-7) and sensitive (sMCF-7) breast cancer lines we investigated the role of MMP-9 in cell migration (CM) and tubular network (TN) formation, two processes implied in tumor growth and metastasis. Our data demonstrate that MMP-9 which is critical for CM is necessary but not sufficient for TN formation and suggest a link between MDR1/P-gp and constitutive MMP-9. Both TN formation and CM are dependent on PKC and ERK1/2 pathways. This study reinforces the logic of combining therefore MMP inhibitors in cancer therapy, especially in patients with chemoresistance and invasion/metastasis. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
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