Journal
GENE EXPRESSION PATTERNS
Volume 7, Issue 1-2, Pages 202-209Publisher
ELSEVIER
DOI: 10.1016/j.modgep.2006.07.005
Keywords
Drosophila; tracheal system; fibroblast growth factor; FGF; branchless; breathless; chitin metabolism; foraging; Stat92E; gasp; gene expression; microarray; anatomical ontology; ImaGO
Categories
Funding
- MRC [MC_U105161047] Funding Source: UKRI
- Medical Research Council [MC_U105161047] Funding Source: Medline
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The embryonic development of the tracheal system of the fruit fly Drosophila provides a paradigm for genetic studies of branching morphogenesis. Efforts of many laboratories have identified Branchless (Bnl, a fibroblast growth factor homologue) and Breathless (Btl, the receptor homologue) as crucial factors at many stages of tracheal system development. The downstream targets of the Bnl/Btl signalling cascade, however, remain mostly unknown. Misexpression of the bnl gene results in specific tracheal phenotypes that lead to larval death. We characterised the transcriptional profiles of targeted over-expression of bnl in the embryonic trachea and of loss-of-function bnl(PI) mutant embryos. Gene expression data was mapped to high-throughput in situ hybridisation based ImaGO-annotation. Thus, we identified and confirmed by quantitative PCR 13 Bnl-dependent genes that are expressed in cells within and outside of the tracheal system. (c) 2006 Elsevier B.V. All rights reserved.
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