Journal
CANCER LETTERS
Volume 291, Issue 1, Pages 120-129Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2009.10.004
Keywords
Hepatocellular carcinoma; Ethanol; Cytochrome P4502E1; Oxidative stress; Mitogenesis
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Funding
- NIH-NIAAA [AA016858]
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Chronic ethanol consumption is a known risk factor for developing hepatocellular carcinoma (HCC). The use of plant-derived antioxidants is gaining increasing clinical prominence as a potential therapy to ameliorate the effects of ethanol on hepatic disease development and progression. This study demonstrates silibinin, a biologically active flayanoid derived from milk thistle, inhibits cytochrome p4502E1 induction, ethanol metabolism and reactive oxygen species generation in HCC cells in vitro. These silibinin-mediated effects also inhibit ethanol-dependent increases in HCC cell proliferation in culture. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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