Journal
CANCER LETTERS
Volume 295, Issue 2, Pages 167-172Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2010.02.022
Keywords
gamma H2AX; Cell cycle; Topoisomerase II; Double-strand breaks; Cytofluorimetric assay
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Resveratrol, a stilbene found in grapes and wine, is one of the most interesting natural compound due to its role exerted in cancer prevention and therapy. In particular, resveratrol is able to delay cell cycle progression and to induce apoptotic death in several cell lines. Here we report that resveratrol treatment of human glioblastoma cells induces a delay in cell cycle progression during S phase associated with an increase in histone H2AX phosphorylation. Furthermore, with an in vitro assay of topoisomerase II alpha catalytic activity we show that resveratrol is able to inhibit the ability of recombinant human TOPO II alpha to decatenate kDNA, so that it could be considered a TOPO II poison. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
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