Lycorine induces apoptosis and down-regulation of Mcl-1 in human leukemia cells

Lycorine is an alkaloid isolated from the bulb of the Amaryllidaceae Lycoris. Here, we report that treatment with lycorine resulted in survival inhibition and apoptosis induction in human leukemia cell lines. Lycorine induced apoptosis in human leukemia cells via intrinsic mitochondira pathway and caused a rapid-turnover of protein level of Mcl-1 which Occurred before caspases activation. Furthermore, pronounced apoptosis accompanied by the clown-regulation of Mcl-1 was also observed in blasts from patients with acute myeloid leukemia. Our findings suggest that lycorine may be a good candidate therapeutic agent against leukemia in worth of further evaluation. (c) 2008 Elsevier Ireland Ltd. All rights reserved.