Journal
CANCER LETTERS
Volume 281, Issue 2, Pages 151-161Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2009.02.025
Keywords
TrkB; Ovarian cancer; Cell migration; Invasion; Apoptosis
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Funding
- University of Hong Kong Committee on Research and Conference Grant
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In this report, we demonstrated that overexpression of tropomyosin-related kinase B (TrkB) was associated with shorter survival in ovarian cancer patients. Brain-derived neurotrophic factor (BDNF), the TrkB ligand, induced activation (phosphorylation) of TrkB in a dose dependent manner. Besides demonstrating the effect of BDNF/TrkB pathway in enhancing cancer cell migration and invasion but inhibiting apoptosis, we also report for the first time that exogenous hepatocyte growth factor induced TrkB expression at both mRNA and protein levels as well as phosphorylation. Our findings suggest that BDNF/TrkB pathway is important in ovarian carcinogenesis and TrkB may be a potential therapeutic target for ovarian cancer. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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