Journal
CANCER LETTERS
Volume 284, Issue 1, Pages 80-85Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2009.04.013
Keywords
Breast cancer; Mesenchymal stem cell; Invasion; CCL5 (RANTES); Matrixmetalloproteinase 9
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Funding
- Department of Defense Breast Cancer Research Program [W81XWH-08-1-0523 01]
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In the present study, we investigated whether human adipose tissue derived stem cells (hASCs) could enhance tumor invasion and whether these hASCs could be a potential source of CCL5. We observed a significant increase in the number of breast cancer cells that invaded the matrigel when Co-cultured with hASCs. We found that hASCs produce CCL5 in the Co-culture and cancer cell invasion was diminished by an antibody against CCL5. Furthermore, cancer cell invasion in the Co-culture was associated with an elevated level of MMP-9 activity. We conclude that CCL5 plays a crucial role for tumor invasion in the interplay of tissue resident stem cells from the fat tissue and breast cancer cells. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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