Journal
CANCER LETTERS
Volume 283, Issue 1, Pages 108-117Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2009.03.031
Keywords
Haematococcus pluvialis; Astaxanthin; Cell cycle; Apoptosis; Cell survival; Human colon cancer cells
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Funding
- MIUR-D1
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The growth-inhibitory effects of the astaxanthin-rich Haematococcus pluvialis were studied in HCT-116 colon cancer cells. H. pluvialis extract (5-25 mu g/ml) inhibited cell growth in a dose- and time-dependent manner, by arresting cell cycle progression and by promoting apoptosis. At 25 mu g/ml of H. pluvialis extract, an increase of p53, p21(WAF-1/CIP-1) and p27 expression (220%, 160%, 250%, respectively) was observed, concomitantly with a decrease of cyclin D1 expression (58%) and AKT phosphorylation (21%). Moreover, the extract, at the same concentration, strongly up-regulated apoptosis by modifying the ratio of Bax/Bcl-2 and Bcl-XL, and increased the phosphorylation of p38, JNK, and ERK1/2 by 160%, 242%. 280%, respectively. Growth-inhibitory effects by H. pluvialis were also observed in HT-29. LS-174, WiDr, SW-480 cells. This study suggests that H. pluvialis may protect from colon cancer. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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