Journal
CANCER LETTERS
Volume 282, Issue 1, Pages 1-8Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2008.11.016
Keywords
Gastric cancer; Helicobacter pylori; Virulence factors; CagA; VacA
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Funding
- National Institutes of Health, United States [R01 CA111533, R21 CA125126]
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Helicobacter pylori infection is the most important risk factor in the development of non-cardia gastric adenocarcinoma; host genetic variability and dietary co-factors also modulate risk. Because most H. pylori infections do not cause cancer, H. pylori heterogeneity has been investigated to identify possible virulence factors. The strongest candidates are genes within the cag (cytotoxin-associated antigen) pathogenicity island, including the gene encoding the CagA protein, as well as polymorphic variation in the VacA vacuolating exotoxin and the blood group antigen binding adhesin BabA. Improved understanding of the pathogenesis of H. pylori-associated gastric cancer may improve risk stratification for prevention and therapy. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
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