Journal
CANCER LETTERS
Volume 275, Issue 2, Pages 185-193Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2008.10.015
Keywords
Cancer stem cells; Tumour-initiating cells; Hepatocellular carcinoma; Colorectal carcinoma; Migration
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Funding
- German Cancer AID (Deutsche Krebshilfe)
- German Federal Ministry of Education and Research (BMBF)
- Heidelberger Stiftung Chirurgie
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Recent findings suggest that the presence of cancer stem cells could be linked with patients' survival. We profiled suggested cancer stem cell markers in tissue specimens of hepatocellular carcinoma and colorectal carcinoma liver metastases. About 1% of cells co-expressed cancer stem cell antigens, but there was no correlation between the amount of CD133(+), CD133(+)/CD44(+) or CD133(+)/CD24(-) cells and the patients' clinical-pathological status or with the cancer stem cell marker-positive cells localization. CD133(+) and CD133(-) fractions of Huh7 cells did not differ in migratory properties. Therefore, presence of markers alone should be taken with caution as single prognostic parameters. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
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