Journal
CANCER LETTERS
Volume 279, Issue 1, Pages 8-12Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2008.09.030
Keywords
Notch; Stem cell; Cancer; Signal pathway
Categories
Funding
- National Cancer Institute, NIH [5R01CA101870]
- Department of Defense Postdoctoral Training Award [W81XWH-08-1-0196]
- University of Texas MD Anderson Cancer Center through a SPORE grant [IP20-CA010193-01]
Ask authors/readers for more resources
The Notch signaling pathway is known to be responsible for maintaining a balance between cell proliferation and death and, as such, plays important roles in the formation of many types of human tumors. Recently, Notch signaling pathway has been shown to control stem cell self-renewal and multi-potency. As many cancers are thought to be developed from a number of cancer stem-like cells, which are also known to be linked with the acquisition of epithelial-mesenchymal transition (EMT); and thus suggesting an expanding role of Notch signaling in human tumor progression. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available