Journal
MICROSURGERY
Volume 27, Issue 4, Pages 324-327Publisher
WILEY
DOI: 10.1002/micr.20365
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Funding
- NIDDK NIH HHS [DK058316] Funding Source: Medline
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK058316] Funding Source: NIH RePORTER
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Islet transplantation is an alternative to whole pancreas transplantation in curative therapy of diabetics. The outcome of engraftment of islet, however, remains disappointing. Rapid and adequate islet revascularization is crucial for the survival and function of transplanted islets. In this study, hepatic stellate cells (HSC) were cotransplanted with islet allografts, achieving marked prolongation of islet allografts. This was associated with enhanced revascularization within islet grafts as determined by anti-CD31 antibody staining. (C) 2007 Wiley-Liss, Inc. Microsurgery 27:324-327, 2007.
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