Journal
CANCER LETTERS
Volume 283, Issue 1, Pages 52-58Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2009.03.024
Keywords
Caspase-6; Cell cycle; Hepatocellular carcinoma; p53; Proliferation; ZBP-89
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Funding
- Research Grants Council of the Hong Kong SAR [CUHK4551/05]
- Public Heath Service Grant [R01 DK-55732]
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ZBP-89 inhibits the some tumor cells but its role in HCC is unknown. We investigated effect of ZBP-89 on cell death of 5 HCC cell lines with different status of p53. We found that ZBP-89 significantly induced cell death of all HCC cells particularly those with wild-type p53. The inhibition was well correlated with the induction of caspase-6 activity. The inhibition of caspase-6 abolished the effect of ZBP-89. ZBP-89 reduced the cells in G2-M but increased them in S phase. With the changes in caspase-6 and cell cycle, ZBP-89 greatly enhanced the killing effectiveness of 5-fluorouracil or staurosporine in HCC cells. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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