Journal
CANCER LETTERS
Volume 281, Issue 2, Pages 196-202Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2009.02.045
Keywords
Valproic acid; Bladder cancer; HTB5; HTB9; Muscle invasive
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Funding
- University of Colorado Cancer Center and Department of Surgery - School of Medicine Academic Enrichment Funds
- Dept of Urology, Seoul National University Bundang Hospital, Bundang-gu, Seongnam, Republic of Korea
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High grade invasive bladder cancer is a leading cause of cancer deaths and treatment options are limited for this type of cancer. Recent studies have reported anticancer effects of valproic acid in many cancers and also in superficial bladder cancer. Acute valproic acid administration suppressed cell proliferation in a time- and dose-dependent mariner in two muscle-invasive human bladder cancer cell lines (HTB5 and HTB9), with accompanying G1 phase cell cycle arrest. A significant decrease in colony formation ability and invasiveness; was seen with valproic acid treatment though the effectiveness varied with cell type. Our results suggest a role for valproic acid in inhibiting growth and invasion of muscle-invasive bladder cancer. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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