Journal
CANCER LETTERS
Volume 284, Issue 1, Pages 15-20Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2009.04.004
Keywords
Sulforaphane; Isothiocyanates; Pharmacokinetics; Chemoprevention
Categories
Funding
- Association for international Cancer Research
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The plasma pharmacokinetic characteristics of the chemopreventive isothiocyanate sulforaphane were determined in six human volunteers following single and repeated intake of raw broccoli. Initially, an analytical method utilising LC-MS/MS, capable of determining low levels of sulforaphane in human plasma was developed and validated. The plasma profile of the isothiocyanate best fitted a two-compartment pharmacokinetic model. Sulforaphane was rapidly absorbed with peak plasma levels being attained within 1.5 h, and was characterised by a long terminal elimination phase. Repeated intake of broccoli had no impact on the pharmacokinetic behaviour or plasma levels of sulforaphane, and there was no evidence of accumulation. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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