Journal
CANCER LETTERS
Volume 284, Issue 2, Pages 222-228Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2009.04.030
Keywords
Antiangiogenic therapy; 16K hPRL; Cationic liposomes; Transfection
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Funding
- Fonds pour la Recherche Industrielle et Agricole (FRIA)
- Fonds National de la Recherche Scientifique (FNRS)
- region wallonne
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Human 16K PRL (16K hPRL) is a potent inhibitor of angiogenesis both in vitro and in vivo. It has been shown to prevent tumor growth in three xenograft mouse models. Here we have used a gene transfer method based on cationic liposomes to produce 16K hPRL and demonstrate that 16K hPRL inhibits tumor growth in a subcutaneous B16F10 mouse melanoma model. Computer-assisted image analysis shows that 16K hPRL treatment results in the reduction of tumor vessel length and width, leading to a 57% reduction in average vessel size. We thus show, for the first time, that administration of the 16K hPRL gene complexed to cationic liposomes is effective to maintain antiangiogenic activities of 16K hPRL level. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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