Journal
CANCER LETTERS
Volume 286, Issue 2, Pages 189-195Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2009.05.025
Keywords
Interleukin-18 (IL-18); Transferrin; Proliferation; Breast cancer
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Funding
- Korea Science & Engineering Foundation (KOSEF) through the Research Center for Women's Disease (RCWD)
- Korea Research Foundation
- Korean Government (MOEHRD) [KRF-2006-005-J02202]
- Seoul Research and Business Development Program [10582]
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Interleukin-18 (IL-18) has recently been shown to have a pro-cancer effect in various cancers. Increased serum levels of both IL-18 and transferrin in cancer patients are correlated with its malignancy. However, the relationship between transferrin and IL-18 is not well understood. Here, we show that exogenous transferrin enhanced breast cancer cell proliferation and the proliferation rate was reduced when endogenous transferrin expression was inhibited by transferrin siRNA. The expression of endogenous transferrin was found to be regulated by IL-18. Furthermore, we found that the MAPK pathway is involved in IL-18-induced transferrin production. In conclusion, IL-18 is suggested as an inducer of endogenous transferrin expression in breast cancer cells. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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