Journal
HETEROATOM CHEMISTRY
Volume 18, Issue 4, Pages 381-389Publisher
WILEY-HINDAWI
DOI: 10.1002/hc.20309
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A one-pot liquid-phase combinatorial synthesis of 2-(4-oxo-4H-1-benzopyran-3-yl)-4-thiazolidinones bearing diverse substituents at the 3-position under microwave irradiation was successfully performed using 3-formyl chromone, primary amine, and mercaptoacetic acid as reactants. Compared to an identical library generated by conventional parallel synthesis, the microwave-assisted parallel synthesis approach dramatically decreased the reaction time from an average of 9 h to 5 min, and substantially increased the product yields. The coupling of microwave technology with liquid-phase combinatorial synthesis constitutes a novel and particularly attractive avenue for the rapid generation of structurally diverse libraries. (c) 2007 Wiley Periodicals, Inc.
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