Journal
CANCER LETTERS
Volume 273, Issue 1, Pages 114-121Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2008.07.035
Keywords
FMG; Syncytia; NF-kappa B; HSP70; Nuclear translocation
Categories
Funding
- Major State Basic Research Development Program of China (973 Program) [2004CB518801]
- National High Technology Research and Development Program of China (863 Program) [2007AA021203]
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Viral fusogenic membrane glycoproteins (FMGs) are new therapeutic genes for the control of tumor growth, the cellular mechanisms mediating cell death is non-apoptotic. However, the precise molecular mechanism remains to be elucidated. Here, we showed overexpression of HSP70 in HL-60 cells mediated by Gibbon Ape leukemia virus hyperfusogenic envelope protein (GALV-FMG) inhibited the nuclear translocation of p65, the transcriptive activity of NF-kappa B and prevented the degradation of I kappa B. NF-kappa B may negatively regulate HSP70 expression, which made a positive feed back loop for expression of HSP70. FMG expression in HL-60 cells leaded to the formation of multinucleated syncytia and cell death, the main death mode of cells is necrosis. This form of cell death should be effective in vivo, gene therapy basing on FMG deserve further study for the treatment of AML. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
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