Journal
TRENDS IN BIOTECHNOLOGY
Volume 25, Issue 9, Pages 401-408Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibtech.2007.07.004
Keywords
-
Categories
Funding
- NIA NIH HHS [AG25371] Funding Source: Medline
- NIDDK NIH HHS [DK073731] Funding Source: Medline
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R21DK073731] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R21AG025371] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Mammalian cell-derived protein therapeutic production has changed the landscape of human healthcare in the past two decades. The importance of protein therapeutics has motivated the search for more cost-effective and efficient cell lines capable of producing high quality protein products. The factors contributing to optimal producer cell lines are often complex, and not simply conferred by one gene or gene product, which makes an understanding of system-wide properties for better engineering of optimized cell lines essential. Genome-scale technologies (genomics, transcriptomics and proteomics) enable such engineering studies. However, the use of these technologies in cell culture engineering is still in its infancy. Here, we summarize current knowledge of cell properties important for the design of efficient protein-producing mammalian cell lines, and highlight relevant studies to-date that use genome-scale technologies in these cell systems. We also provide a focused review of relevant alternative and emerging technologies, which have seen limited use in cell culture engineering, but hold great potential for significant advancements in protein therapeutic production.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available