Journal
CANCER LETTERS
Volume 259, Issue 1, Pages 39-49Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2007.09.015
Keywords
pancreatic cancer; apigenin; gemcitabine; Akt; NF-kappa B
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Apigenin is a dietary flavonoid possessing therapeutic potential against cancers. This study was designed to investigate whether combination therapy with gemcitabine and apigenin enhanced anti-tumor efficacy in pancreatic cancer. In vitro, the combination treatment resulted in more growth inhibition and apoptosis through the down-regulation of NF-kappa B activity with suppression of Akt activation in pancreatic cancer cell lines (MiaPaca-2, AsPC-1). In vivo, the combination therapy augmented tumor growth inhibition through the down-regulation of NF-kappa B activity with the suppression of Akt in tumor tissue. The combination of gemcitabine and apigenin enhanced anti-tumor efficacy through Akt and NF-kappa B activity suppression and apoptosis induction. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
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