Journal
CANCER LETTERS
Volume 266, Issue 2, Pages 163-170Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2008.02.058
Keywords
CD82/KAI-1; E-cadherin; beta-catenin; cancer invasion; cell adhesion
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In this study, we analyzed the effect of the metastasis suppressor CD82/KAI-1, a member of the tetraspanin superfamily, on intercellular adhesion on cancer cells. The newly established invasion assay and the cell aggregation assay revealed that CD82 strengthens E-cadherin-mediated intercellular adhesion. Interestingly, ectopic expression of CD82 stabilized E-cadherin/beta-catenin complex formation. Furthermore, CD82 reduced tyrosine phosphorylation of beta-catenin on HGF stimulation. Taken together, CD82 may stabilize or strengthen E-cadherin-dependent intercellular adhesion by regulating catenin-mediated signal transduction on cancer cells, and consequently, prevent cancer cells from seceding from the primary tumor site. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
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