Journal
CANCER LETTERS
Volume 265, Issue 2, Pages 157-166Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2008.02.066
Keywords
cortactin; tumor; invasion; migration; invadopodia
Categories
Funding
- NIDCR NIH HHS [1R21DE018244, R21 DE018244-01, R21 DE018244] Funding Source: Medline
- NIGMS NIH HHS [R01 GM075126, R01 GM075126-01A2, 1R01GM075126] Funding Source: Medline
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Cortactin is a cytoskeletal protein and src kinase substrate that is frequently overexpressed in cancer. Animal studies suggest that cortactin overexpression increases tumor aggressiveness, possibly through promotion of tumor invasion and metastasis. Recently, many studies have documented a role for cortactin in promoting cell motility and invasion, including a critical role in invadopodia, actin rich-subcellular protrusions associated with degradation of the extracellular matrix by cancer cells. Here, I review the evidence and potential mechanisms for cortactin as a critical mediator of tumor cell invasion. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
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