Journal
CANCER LETTERS
Volume 263, Issue 1, Pages 61-66Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2007.12.016
Keywords
oxidation potential; flavonoid; Epstein-Barr virus early antigen; cyclic voltammetry
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The oxidation potentials of fifteen flavonoids in phosphate buffer at pH 7.2 were determined by cyclic voltammetry. A good correlation was found between these oxidation potentials and the ability of flavonoids to inhibit Epstein-Barr virus early antigen (EBV-EA) activation. Furthermore, multiple regression analysis revealed that the solvent-accessible surface area (SASA) was a useful parameter for estimating the inhibitory effects of flavonoids on EBV-EA activation. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
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