Journal
LETTERS IN DRUG DESIGN & DISCOVERY
Volume 4, Issue 4, Pages 246-248Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/157018007784620068
Keywords
fendiline; antileukemic compounds; diphertylmethanes
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A series of novel, 2'-substituted derivatives of fendiline have been synthesised and their ability to inhibit growth of human leukaemia cells (K562) determined. Of these derivatives, the 2'-hydroxy compounds 26 and 27 had a significantly greater inhibitory effect on K562 cells than fendiline.
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