Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 19, Issue 3, Pages 298-304Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2007.04.001
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Funding
- Austrian Science Fund FWF [P 17871] Funding Source: Medline
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Lamins, together with the lamin-associated proteins of the inner nuclear membrane, are structural proteins in the nucleus that mediate mechanical stress resistance. Novel findings show that lamin complexes also have scaffolding functions in the formation and regulation of higher order chromatin and in epigenetic regulatory pathways. Furthermore, lamins serve as scavenging complexes and regulators of signaling molecules in diverse pathways. Lamin complexes in the nuclear interior contribute to retinoblastoma-mediated cell cycle regulation. Because of their multiple and diverse roles, lamins are linked to an increasing number of human diseases. The molecular mechanisms of these diseases, which are just beginning to emerge, may involve cell cycle and differentiation defects in adult stem cells and genomic instability.
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